Monthly Archives: April 2014

Confronting Cancer Quackery

Cancer quackery (along with charlatanism surrounding HIV/AIDs) has to be one of the most noxious of all pseudoscience-based enterprises and, perhaps it’s just my line of work, but I can’t help but feel that it’s on the rise. The reliably high prevalence of cancer represents immensely fertile ground for scammers, and “alternative” treatments for it are sought by millions, supporting a steady cash-flow in the direction of fakes, phoneys, and otherwise ignorant followers of charismatic nasties. As well as fostering a generalised distrust in science and burning holes in wallets, cancer pseudoscience often steers patients away from their one and only shot at survival.

The Internet is abuzz with “natural remedies” and “holistic” measures against cancer, and a quick trawl through some of the websites spouting them reveals that the nature and extent of the errors (and lies) upon which they are based are as varied as they are pernicious. However, two hallmarks crop up invariably: 1, a gross de-emphasis of the complexity and diversity of cancer, and 2, a blurring of the (extremely important) distinction between cancer prevention and cancer cure. Equipped with a basic understanding of how cancer works, cancer pseudoscientists’ lack thereof becomes painfully obvious. They chronically demonstrate ignorance of the most elementary aspects of oncology. It is this very ignorance, combined with a total lack of legal regulation (not to mention endorsement by certain celebrities), that enables them to claim, smilingly, that they have the “secret” to curing cancer. In this short essay, I offer a basic explanation of how cancer works, focussing on the not-widely-enough-appreciated role that evolution, by means of natural selection, plays in tumour-growth and -development. Above all, I aim to facilitate your feeling more confident, in any future debates you might have, that “alternative” cancer-cure pedlars, whether through malice or misguidance, are Full Of Shit.

 

Some necessary background information

I think the best place to start is to consider normal body cells. Unlike free-living cells, such as bacteria, the cells of our body do not compete with each other for their own ‘selfish’ genetic propagation. On the contrary, they co-operate on a huge scale, through a vast network of elaborate communication mechanisms, dividing and assuming designated roles in adherence to instruction and signals, and even committing suicide, on cue, for the interests of the aggregate. This non-rebellious behaviour is of course explained by the fact that body cells are a collection of clones. Co-operative behaviour contributes to the propagation of their genes.

In each somatic cell (that means all cells except sperms and eggs), there is a copy of the body’s genome. Your genome is the sum of all your body’s genetic information, which is organised into 46 chromosomes – 22 pairs of “autosomes” and one pair of sex chromosomes (“XX” or “XY”, depending on whether you are a girl or a boy). Far from being an inaccessible “blueprint”, as it is often dubbed, each cell’s genome is a dynamically active factory, churning out myriad different proteins in response to incoming demands, which are communicated via precise chemical signals that either come from within the cell itself, or originate elsewhere in the body. These signals work by selecting specific stretches of gene sequence (“written” in DNA) to be read off and converted into corresponding protein sequences (which are “written” in amino acids). The number of different proteins produced by cells in the body is estimated to be somewhere in the realms of a couple of million. Each of them coils, bends and folds into its own unique shape, according to the signature of physical interaction that occurs between its constituent amino acids, all of which have slightly different distributions of electrical charge and molecular bonds.

Some of these protein shapes act as building blocks for structures such as muscle and skin, whereas others function as tools for breaking things apart, or putting things together. Some act as vehicles, carrying important stuff around the body, while others work to neutralise germs and viruses that get into us. Yet another class of proteins works in communication, as chemical signals (like those mentioned above), to trigger the production of yet more proteins, perhaps in cells some distance away from the ones in which they themselves were put together. In some cases, a protein’s communication errand entails recognising a certain sequence on a certain chromosome, and sticking to it in order to deactivate a gene, or perhaps cause it to go into programmed hyperactivity, which would result in a concentrated outflow of another specific protein.

So, each copy of the genome (in every cell) acts like a mini factory, and The Genome, in its singlular, more abstract sense, is responsible for matching supply and demand in a vast supersystem of interconnected production, maintenance, communication, and transport subsystems.

The growth and maintenance of this supersystem depends on cells’ ability to make copies of themselves, which is itself based on DNA’s ability to self-duplicate, since every new cell needs its own copy of The Genome. As with any copying system, DNA replication has an inherent, unavoidable error-rate. In the course of a human lifetime, some 10,000,000,000,000,000, (ten thousand million million) cell divisions take place. It is estimated that the probability of an error being made is approximately 0.000001 per gene, per cell division, under normal circumstances (i.e. in the absence of mutagens – substances which promote mutation). It follows that any given gene in The Genome can be expected to have experienced mutation around one million times in one lifetime. Unsurprisingly, evolution has stumbled across a number of mechanisms to fix errors as they arise. Occasionally, however, things do slip through the net. And it is at these moments of accidental neglect that cancer has its chance to begin laying the groundwork for infiltration.

 

So, what is cancer?

Cancer is the product of a collection of genetic alterations that promote “selfish” behaviour in cells, at the expense of the body in which they live. A situation is set up in which natural selection, fuelled by a building momentum of newly-acquired mutations, works (unintentionally, of course), to cultivate an increasingly deviant population of cells that “compete” with their neighbours to proliferate their own mutant genotypes, a phenomenon which begins to manifest as a tumour. In the sense that they are subject to natural selection, tumour cells have started to look quite like unicellular organisms such as bacteria, which, as we know all-too-well, can evolve extremely quickly, thanks to the exponentiating speed with which a cell population can multiply. So, in the case of cancer, what kind of accidentally-acquired traits could flip a perfectly respectable, law-abiding body cell into the realms of cancerous activity? And what “skills” might then be “useful” for it in its selfish accrual of control?

The most obvious power that must be acquired by a somatic (body) cell, via a change in its genome, is that of overcoming restraints on cell division. Cells that begin breaking the rules like this are, in most cases, eventually detected by patrolling immune surveillance mechanisms and sentenced to death by apoptosis, which consists in a signal that commands the cell to digest itself. Thus, by the time detection occurs, for the trajectory of cancer development to continue, another “ability” must have been acquired: that of evading such a signal. A mutation conferring this ability may arise before or after uncontrolled cell division was allowed to begin, but of course one of the numerical implications of increased division is that the absolute rate of copying error is increased, so it follows that an already illegitimately dividing cell lineage has an enhanced likelihood of chancing upon a signal-evasion mutation.

Now, any additional increase in tendency toward DNA mutation represents another “advantageous” trait for a cancer cell in-the-making and, therefore, any mutation that deactivates DNA repair mechanisms, or tampers with DNA copying mechanisms themselves, become favoured. (As a quick aside, when we talk of a “favoured” mutation in this context, we mean one that boosts a cell’s probability of reproducing more prolifically, relative to cells lacking the mutation, and thus becoming increasingly over-represented as a proportion of the population, as this population grows.)

The next barrier a potential cancer cell in a growing mass must overcome is the stringy matrix of proteins that surrounds it, keeping it stationary and contained within its designated area of body tissue. Without the ability to do this, a cell can spawn a mass of abnormal offspring, but this localised tumour can be easily surgically removed. Such a tumour is considered “benign”. Conversely, a tumour whose cells have undergone mutations that allow them to invade and colonise surrounding tissues is considered malignant. Fugitive cells are said to have metastasised, escaping through blood or lymphatic vessels to form secondary tumours, or metastases, in other parts of the body. Once this has happened, it can be very difficult, and often impossible, to eradicate the disease.

 

A “Miracle Cure” for cancer?

Now, in case it hasn’t already become clear that no amount of guanabana juice or religious adherence to a macrobiotic diet could possibly cure cancer, I want to discuss this now.

Cancer is in fact not a disease, but a category of highly diverse diseases, the exact causes of which, both ultimate and proximate, are different in every patient. At this point, I want to distinguish between ultimate and proximate causes. Ultimate causes are things like smoking, drinking, exposure to radiation or UV, inherited predisposition, diet, lack of physical activity, and other things that are yet to be identified. Proximate causes are the specific mutations, conferring the specific traits discussed above, that allow cancer to begin and progress. Loosely speaking, ultimate causes get closer to answering “why”, while proximate causes are more about “how”. Everyone knows that cancers have a lot of different ultimate causes. What a lot of people don’t know is that cancers have an extraordinarily diverse set of proximate causes, too. It is thought that, in most cases, between 5 and 10 mutations, contributing towards the selfish powers outlined above, are needed to create the conditions for metastatic cancer to arise. However, (and crucial for our purposes of winning in a debate in which somebody says that cancer can be cured with megadoses of vitamin C, ginseng tea and bloodroot extract), these mutations may appear in any of thousands of candidate genes. A “favourable” cancer-enabling trait like genetic instability could be achieved through disruption of any of a huge number of possible cellular systems, at any of a huge number of potential stages along the biochemical pathway making up such a system. Since so many genes, and such an immense number of genetic interactions and systems are involved in the regulation of cell behaviour, in any given case, a unique profile of mutations (and therefore a unique set of cellular malfunctions) can give rise to the same cancerous symptoms in cells. This can be seen by looking at the genetic mutations found in tumours from different people suffering from the same form of cancer. While there are some genes that present mutations in a considerable number of cases, most mutations harboured in a cancer cell genome are ones that have never been seen before. In fact, if you compare cells taken from different areas of the same tumour, you find that there is considerable diversity in terms of what has mutated. The more genetically diverse a tumour cell population is, the better its odds, by chance, of harbouring mutations that protect it from potential treatments, so the more likely it is to survive and recoup after an attack from a course of radiotherapy, chemotherapy, or oral medication. Particularly sinister here is that, since the survivors of such an attack become the genetic founders of the subsequently regenerated tumour cell population, any mutations which played a role in allowing the surviving cells to live through such an attack will now be ubiquitous. By the time the tumour has grown back, it will thus be extra-robust: more resistant to future attacks of the same kind, and sporting a whole load of new mutations to boot. This is just one of the reasons why choosing the right treatment, at the right dosage, is absolutely critical.

At the centre of cancer are not “cancer genes”, but an interdependent and vastly complex network of biochemical pathways, all of which are potentially disturbed by mutations in any of the genes involved in making them work. An effective cancer drug therefore needs a very specific mode of action – it needs to attack individual components of a faulty biochemical pathway. In the absence of knowledge of which biochemical pathways have been mutated, there is no way in. We are far from understanding all cellular biochemical pathways, and even further from understanding the precise ways in which each gene is involved in those pathways. What we do know is that it is monstrously and mind-bogglingly convoluted. I hope it’s becoming clear by now just how impossible it is for someone who has not examined the genetic aberrations within a specific tumour, and who does not understand cell biology, to make it go away.

Even if we did have a full documentation and understanding of all the biochemistry going on in cells, the idea of a comprehensive, all-round Cure for Cancer is implausible, due to the sheer number of different genetic and chemical components involved in different different diseases from the cancer category.

Current cancer treatments take advantage of the properties that define cancer cells as distinct from normal cells. For example, some exploit their genetic instability. Ionising radiation, for instance, damages DNA. Both normal and abnormal cells get zapped, but whilst normal cells will arrest their cell cycles until they have repaired it, cancer cells, characterised by their “ability” to ignore damage to their DNA and continue dividing, dying as a result of the catastrophic DNA damage they experience when they attempt to do so with defective chromosomes.

The main defining feature of “Complementary” and “Alternative” Medicine (CAM) cancer ‘treatments’, as compared with science-based cancer treatments (apart from the simple fact that the former do not work, of course) is that, unlike science-based cancer treatments, they are not targeted. Drug targets emerge from what is known about cell biochemistry. Biochemical pathways that are observed to have been disrupted by mutation in a significant number of cancer cases represent places to look for such targets. Their various stages each represent a sort of window through which cellular behaviour might be modulated. Herceptin provides an illustration. The “HER2” gene, which mediates the HER2 pathway, is mutated in 20-30% of breast cancers, causing the over-expression (churning out of too many) HER2 receptor proteins (proteins that sit on cell membranes and act as signal receivers). These receptors receive signals that, via a cascade of cellular events, stimulate the cell to grow and proliferate. Cells with an abnormally large number of HER2 receptors on their surface can grow and proliferate too quickly and too much. Herceptin intersects this pathway by blocking – getting into and jamming – HER2 receptors. In HER2-positive breast cancers (particularly when combined with chemotherapy), this can halt tumour growth. Herceptin’s ability to do this relies upon it having exactly the right molecular shape to fit into its target receptor – just like getting into your target house depends on your having a key that is exactly the right shape to fit its lock. Success of treatment depends on perfect specificity between drug and drug target.

CAM providers’ claims that alkaline water, or coffee enemas, or dietary changes can “cure cancer”, apart from anything else, work on the erroneous assumption that cancer is a single disease, entirely overlooking the diversity that characterises cancer as a disease category, and directs research in oncology. These cancer cure claims can often be identified as phoney by virtue of their also appearing in CAM (or in some cases legitimate) advice on cancer prevention. There are indeed various sensible lifestyle changes that can be made to reduce risk of cancer onset (squirting coffee up one’s behind or daily endeavours to “alkalinise” the body not falling into this class), but once cancer has begun, none of these changes are capable of targeting an already-growing mass of cells.

Incidentally, many phoney cancer-cure claimants invoke the “power of antioxidants” to destroy tumours. This presumably stems from the suggestion that antioxidants can help reduce the risk of cancers developing in the first place. Notwithstanding the fact that the free-radical theory of ageing has been called into question, the reasoning that says “since antioxidants help prevent cancer, flooding already-present cancer with them must help to cure it too” is fallacious. Indeed, in some cases, antioxidants can actually help protect cancer cells that have broken away from their surrounding mesh of protein and would otherwise have died as a result.

While some of the big cheeses in CAM are no doubt ignorant rather than just callous, I’m not sure the distinction is particularly pertinent, since their ignorance is elective. All the information is out there, and making the active decision not to study cancer before taking cancer patients’ lives into one’s hands is shamelessly unethical. Hardly surprising though, since being an oncologist means years of training and difficult exams. CAM practitioners seem to want it all: to avoid ever putting in any effort to really understand cancer pathology, yet reap the satisfaction of being revered as experts; to take patients’ money, but circumvent academic scrutiny. To achieve this, they cheat, lie and manipulate, unconditionally dismissing all evidence against the efficacy of their methods. They demonise oncologists, radiologists and surgeons, labelling them as “Big Pharma shills” who just want to earn the Big Bucks by selling products to patients. Using cherry-picked and misleading statistics, they say that chemotherapy is “poison” – a global conspiracy that “creates customers not cures”. In making this argument, they ignore the fact that countries with national health services, like here in the UK,  offer chemotherapy for free, and that what the statistics really show is that chemotherapy has greatly improved the average cancer sufferer’s prognosis.

Cancer quacks cash in on oncologists’ deeply-held responsibility to be absolutely realistic about what can and cannot be expected from available treatment in any given case, offering failsafe cures where actual doctors could not. As Science-Based Medicine’s David Gorski puts it: “It is ironic that CAM proponents often simultaneously tout how individualized their treatment approach is, but then claim that one product or treatment can cure all cancer. Meanwhile they criticize the alleged cookie-cutter approach of mainstream medicine, which is actually producing a more and more individualized (and evidence-based) approach to such things as cancer.”

Our only weapon against CAM’s Crimes Against Humanity is education. Next time someone casually mentions that cancer can be cured “from within”, or that “acid degradation of cells” is what causes tumours, don’t let it slide!

 

johnson This 1908 advertisement offered a 125-page book of patient testimonials as proof of the value of “Dr. Johnson’s Mild Combination Treatment for Cancer.” Testimonials—genuine or fabricated—often are the most effective sales ammunition for quack products, and the easiest to obtain. Drugs that work are supported by scientific evidence obtained from carefulIy controlled tests.

(picture and accompanying blurb from cancertreatmentwatch.org)

 

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Government Experiments Reveal Humans Are Capable Of Bending Physical Objects With Their Mind (…or not)

An article entitled “Government Experiments Reveal Humans Are Capable Of Bending Physical Objects With Their Mind”, hosted at colllective-evolution.com and other conspiracy and pseudoscience websites, references only two sources, neither of which live up to the promise that “this-is-something-all-humans-are-capable-of-heres-the-proof”, as laid out in the article’s URL.

ImageThe first of these sources is a truly mind-warping document, entitled “Teleportation Physics Study” which, it transpires, was funded by the US Air Force, for the price of $25,000 – a drop in the ocean compared to the millions of dollars its rather obscure author, Eric Davis, urges be spent on further research into the areas he covers therein. These include quantum teleportation, traversable wormholes, and…psychic teleportation – AKA psychokenisis (PK). Physics professor and famed sceptic Lawrence Krauss describes Davis’ report (a more fitting term than “study”) as “in large part crackpot physics,” with “some things adapted from reasonable theoretical studies, and other things from nonsensical ones.” As anybody who has read or watched “Men Who Stare at Goats” will know, the military has a well-documented pseudoscience track-record, and its penchant for quackery and mumbo-jumbo continues into the 21st century.

 In the psychokinesis section of the Teleportation Physics report, Davis cites (apparently without even a hint of irony) the notorious “PK parties'” run by Jack Houck in the 80s, in which Houck believed he could teach guests how to heat up metal with their minds to make it soft and pliable. (Michael Shermer attended one of these and was able to show, with the help of microscope analysis, despite Houk’s strong convictions to the contrary, that the bent spoons produced by the guests, allegedly using a mixture of mechanical and psychic force, had been caused purely by the former, showing no signs of structural alteration by heat.) Davis also describes “psychic Uri Geller” as “the original model for demonstrating PK metal bending” – again, apparently in total sincerity. See below for entertaining links on the denuding of Gellar’s many incidents of fraud.

Houck and Geller have both been comprehensively debunked – typing their names into Google followed by “sceptic” or “debunked” will attest bountifully to their undazzlingness. However, slightly more ruffling than reference to a known con-artist and a deluded fantasist, later in the same section on psychokenisis, Davis cites a handful of obscure Chinese studies, mostly from the early 90s, involving “gifted” people with “extraordinary PK ability” who were allegedly able to make solid objects like watches and horsflies “meld” with walls, and teleport across rooms. Davis claims, with remarkable confidence, that “the experimental results were all repeatable”, and that “the conditions for fraud and sleight of hand were totally eliminated, and multiple independent outside witnesses (technical and military-intelligence experts) were present at all times to ensure total fidelity of the experiments”. His hyperbolic expression of confidence in the openness and authenticity of these studies (particularly given their political context) seems almost fanatical. Suspiciously, three of the four Chinese studies he mentions come from issue 1 of the ‘Chinese Journal of Somatic Science’. I can’t track down any of these papers online. However, let’s just say that, apart from anything else, Davis’ extraordinary failure to notice Geller’s so richly established status as fraudster does not bode at all well for his ability to detect dodgy experimental design or the dubious interpretation/reporting of results so common in parapsychology research (see links below). Moreover, scientists are in no way impervious to the illusions of stage magic – Project Alpha, for instance, saw fake psychics dupe researchers for over four years, stringing them along for over 160 hours’ worth of experiments on their “paranormal” abilities.

Davis also spends a few paragraps talking about all the millions of dollars that the Soviet Union and its Warsaw Pack allies invested in “psi” research, including “psychotronics, human mind/behavior control, and the entire spectrum of parapsychology”. Davis never actually explains what exactly this research was able to show, and instead just assures us that it represents a “wealth of experimental data”. He also describes the Soviet Union’s “revolutionary techniques” for influencing human behaviour, which they called “controlled offensive behaviour”, in the same breath as stating that the research initiative of this era had been influenced and informed by material gained from Nazi research centres in and around Germany at the end of WWII. Ooof.

The second source referenced in the collective-evolution.com article, in case you are interested, is a document entitled “PK Party Format and Materials Required“, in which Jack Houck basically lays down the itinerary for his whacky psychokinesis workshops. He talks about (but fails to provide) electron microscopic pictures of his PK-assisted bent spoons vs control spoons bent with “only” mechanical force, explaining that he shows these pictures to his attendees, “to give some scientific credibility to the phenomena”. As mentioned above, Michael Shermer enlisted the help of a metal specialist to analyse the structure of Houk’s spoons. They fitted the profile for mechanically-bent metal, with no signs of thermal structure alteration.

Government experiments from the Cold War era may well have claimed to reveal that humans are capable of bending physical objects and getting horsflies to teleport (not fly!) across rooms, but the incentive to trust these claims is snivellingly low, and these results have not been replicated in other laboratories. If the experiments Davis cites are “all repeatable” and “rigorously controlled”, why has nobody repeated them, and collected the $1,000,000 James Randi has pledged to the first person who can demonstrate the occurence of a supernatural event under controlled conditions?

Bottom line? When you strip away the hype and outright falsities from the collective-evolution.com article, what you are left with is a picture which actually shows that despite the millions of dollars spent by the US military and the former USSR, all we have in support of psychokinesis and paranormal abilities are studies that are either debunked or so obscure as to be unavailable to your average Google-user. Since we have failed to find evidence for it in any of the places we have looked, the absolute best we can say for the paranormal it is that, if it does exist, we have no idea what it might do, how it might operate, or where to find it.

I would love you to dip into the Davis report and comment, especially if you are a physicist.

 

http://www.donotlink.com/fSM – Original article at Collective Evolution

http://www.youtube.com/watch?v=NnDHPOWXFVI – James Randi exposes Uri Geller

http://www.indian-skeptic.org/html/fey2.htm – Richard Feynman meets Gellar and is disappointed, not just with his failure to demonstrate his psychic powers, but also his failure to do any impressive magic tricks

http://rationalwiki.org/wiki/Parapsychology – Great article on the failings of parapsychology as a field

http://www.skepdic.com/parapsy.html – Skeptics’ dictionary entry on parapsychology – goes into some of the most common problems with experiments that researchers have claimed support the existence of ESP